General Information

UPHSM LIS Test #: 027390
Testing Time: 4-9 Days
Testing Lab: Labcorp

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 10 mL of 24 hour Urine
Temperature: Refrigerate
Tube Type: Plastic 10 mL Urine Container
Collection Info:
Specimen:  Urine (24-hour)
Volume:  10 mL
Minimum Volume:  1 mL (Note: This volume does not allow for repeat testing.)
Container:  Plastic urine container with no preservative

Collection:  Instruct the patient to void at 8 AM and discard the specimen.
Then collect all urine including the final specimen voided at the end of the
24-hour collection period (ie, 8 AM the next morning) into the plastic urine
container. Screw the lid on securely. Transport the specimen promptly to the
laboratory. Container must be labeled with patient's full name, date and time
collection started, and date and time collection finished. pH must be 4-8.

Patient Preparation:  If patient is taking diuretics, antihypertensive drugs, cyclic
progestational agents, estrogen, or licorice, results for aldosterone may not be
interpretable. Patient should be on a diet containing 135 mmol (3 g) sodium per
day for at least two weeks and preferably 30 days prior to testing.

Causes for Rejection:  Incomplete 24-hour collection; original container with pH <2


Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Clinical Utilities

Use:  Study of adrenocortical-renin-angiotensin system; adrenal cortical
function test; evaluate renal hypertension; diagnose Conn syndrome
(primary aldosteronism); evaluate hypokalemia with hypertension

Limitations:  Urinary aldosterone measurements alone are of limited value
in the diagnosis of hyperaldosteronism. Elevated levels mandate further investigation.

CPT Codes


* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range


• 0-3 days: 0.00-5.00 μg/24 hours

• 4 d-10 years: 0.00-8.00 μg/24 hours

• >10 years: 0.00-19.00 μg/24 hours


• Low sodium intake: 20.00-80.00 μg/24 hours

• Normal sodium intake: 0.00-19.00 μg/24 hours

• High sodium intake: 0.00-12.00 μg/24 hours