GLUCAGON PLASMA

General Information

HLAB/HOL Code: GLUCA
UPHSM LIS Test #: 027660
Schedule:
Testing Time: 3-7 Days
Testing Lab: Mayo

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 2.0 mL
Temperature: Frozen
Tube Type: Plasma (EDTA)
Collection Info:
Patient Preparation: Fasting (8 hours)
Collection Instructions:
1. Pre-chill tube at 4 degrees C before drawing the specimen.
2. Draw into the pre-chilled tube, and process as follows:
    a. After drawing specimen, chill tube in wet ice for 10 minutes.
    b. Centrifuge in a refrigerated centrifuge or in chilled centrifuge carrier.
    c. Immediately after centrifugation, aliquot plasma into a plastic vial, and freeze.

Specimen Acceptability

REJECT DUE TO:
Gross hemolysis: Reject
Gross lipemia: OK
Gross icterus: OK

Methods

Immunoassay

Clinical Utilities

Diagnosis and follow-up of glucagonomas and other glucagon-producing tumors
Assessing diabetic patients with problematic hyper- or hypoglycemic episodes (extremely limited utility)

CPT Codes

82943

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

< or =6 hours: 100-650 pg/mL
1-2 days: 70-450 pg/mL
2-4 days: 100-650 pg/mL
4-14 days: declining gradually to adult levels
>14 days: < or =80 pg/mL (range based on 95% confidence limits)
Glucagon levels are inversely related to blood glucose levels at all ages. This is particularly pronounced at birth and shortly thereafter, until regular feeding patterns are established. This explains the higher levels immediately after birth, which then first fall as the glucagon release mobilizes the infant's glucose stores, then rise again as stores are depleted, finally normalizing towards adult levels as regular feeding patterns are established.