METANEPHRINES FRACTIONATED FREE PLASMA

General Information

HLAB/HOL Code: METHP
UPHSM LIS Test #: 6883
Schedule:
Testing Time:
Testing Lab: Labcorp

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 1.0 (0.4) mL Plasma
Temperature: Refrigerated
Tube Type: 1 Lavender Top EDTA
Collection Info:
Specimen:  Plasma

Volume:  1.0 mL

Minimum Volume: 0.4 mL

Container:  Lavender-top (EDTA) tube

Collection:  Draw blood in chilled lavender-top (EDTA) tube. Invert to mix with preservatives.
Centrifuge and transfer the plasma to a labeled plastic transport tube (Note: The whole blood
sample may be kept refrigerated at 4°C for as long as two hours before centrifugation, if necessary).

Storage Instructions:  Refrigerate

Patient Preparation:  Patient should be fasting overnight (water and noncaffeinated soft drinks
are permissible). The patient should be in a supine position for at least 15 minutes before and
during sample collection. An indwelling venous catheter (normal saline to keep the line patent)
is recommended, since the acute effects of the stress of venipuncture may increase metanephrine.
It is preferable, but not essential, to draw the sample without a tourniquet.

Causes for Rejection:  Specimen not drawn in correct tube; heparinized plasma received

Methods

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-/MS)

CPT Codes

83835

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

Normetanephrine: 0-145 pg/mL
Metanephrine: 0-62 pg/mL

Concentrations of normetanephrine between 146 and 487 pg/mL and metanephrine between 63 and 255 pg/mL are considered indeterminate. Follow-up biochemical testing is recommended when patient levels fall within this indeterminate range. These tests include repeat testing of plasma/urinary fractionated metanephrines and plasma catecholamines.