General Information

UPHSM LIS Test #: 1424
Schedule: Monday - Friday
Testing Time: 1 - 3 days
Testing Lab: Marquette General Hospital

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 3.0 mL Bone Marrow or 5.0 mL Blood
Temperature: Ambient
Tube Type: Bone Marrow or Malignant Blood
Collection Info:
Bone Marrow is the tissue of choice for initial diagnosis of most neoplastic specimens. Malignant blood can be used in certain cases to monitor minimal residual disease.  Prefer a minimum of 3.0 mL of bone marrow or 5.0 mL of malignant blood. Draw into green-top (sodium heparin) tube(s), invert several times to mix (clotted specimens may not work and can compromise results).  Label vial with the patient's name and a unique identifying number (MGHS encounter # or MR #). Maximum time from collection should be 24 hours.


Interphase set-up and analysis. A minimum of 500 interphase nuclei will be analyzed.

Clinical Utilities

Diagnosis of API2-MALT1 gene fusion characteristic of t(11;18)(q21;q21) associated with marginal zone B-cell lymphoma of Mucosa-Associated Lymphoid Tissue (MALT).

CPT Codes

88271x2 (DNA probe, each), 88275x2 (Interphase in situ hybridization), 88291 (interpretation and reporting). The following CPT codes are added at additional charge when needed: 88237 (Cell culture, neoplastic blood or bone marrow).

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

0-0.6% Fusion = Normal
Above 0.6% fusion = Abnormal