FISH ANALYSIS CCND1/IGH

General Information

HLAB/HOL Code: FISH
UPHSM LIS Test #: 1514
Schedule: Monday - Friday
Testing Time: 1 - 3 days
Testing Lab: UP Health System-Marquette

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 3.0 mL Bone Marrow or 5.0 mL Blood
Temperature: Ambient
Tube Type: Bone Marrow or Malignant Blood
Collection Info:
Prefer a minimum of 3.0 mLof bone marrow or 5.0 mL of malignant blood.  Draw into green-top (sodium-heparin) tube(s), invert several times to mix.  Clotted specimens may not work and can compromise results. Label vial with patient's name and a unique identifying number (MGH encounter # or MR #). Maximum time from collection should be 24 hrs.
SPECIMENS CANNOT BE FROZEN

Methods

Interphase set-up and analysis. A minimum of 500 interphase nuclei will be analyzed.

Clinical Utilities

Diagnosis of CCND1/IGH gene fusion characteristic of the t(11;14)(q13;q32) most commonly associated with
mantle cell lymphoma or multiple myeloma.

CPT Codes

88271x2 (DNA probe, each), 88275x2 (Interphase in situ hybridization), 88291 (Interpretation and Reporting). The following CPT's are added at additional charge when needed: 88237 (Cell culture- lymphocytes).

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

0-0.6 % fusion = Normal
Above 0.6% fusion = Abnormal