General Information

UPHSM LIS Test #: 5446
Schedule: Monday - Friday
Testing Time: 2 - 5 days
Testing Lab: UP Health System-Marquette

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 3.0 mL of BM or 5.0 mL of Blood
Temperature: Ambient or Refrigerated
Tube Type: 1 Sodium heparin (green top)
Collection Info:
Prefer a minimum of 3.0 mL of bone marrow or 5.0 mL of whole blood. Draw into green-top (sodium heparin) tube (s), invert several times to mix (clotted specimens may not work and can compromise results). Label vial with patient's name and a unique identifying number. Maximum time from collection should not exceed 24 hrs.


Interphase set-up and analysis up to 200 cells for 1q, 17p-, CEN 3/CEN 7; and CEN 9 /CEN 11; up to 500 cells for t(11;14) CCND1/IGH fusion. Reflex to t(4;14), t(14;16) and t(14;20) as clinically indicated.

Clinical Utilities

Detection of abnormalities involving 1q amplification, 17p, CEN 3/CEN 7, CEN 9/CEN 11, t(4;14), t(11;14) or t(14;16) translocations most commonly associated with myeloma, MGUS or plasma cell dyscrasia. t(4;14), t(14;16), and t(14;20) performed as reflex testing only, unless specifically requested or patient has previous history.

CPT Codes

Whole Bone Marrow:
88271 x 10 DNA probe, each
88275 x 5 Interphase in situ Hybridization

Plasma Cell Enrichment:
88271 x 10 DNA probe, each
88275 x 2 Interphase in situ Hybridization

Additional as needed:
88237 Cell Culture-BM/Malignant Blood
88271 DNA probe, each
88275 Interphase in situ Hybridization

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

An interpretive report will be provided.