FISH ANALYSIS CLL PANEL

General Information

HLAB/HOL Code: FISH
UPHSM LIS Test #: 0064
Schedule: Monday - Friday
Testing Time: 2 - 5 days
Testing Lab: UP Health System-Marquette

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 3.0 mL Bone Marrow or 5.0 mL Blood
Temperature: Ambient
Tube Type: Bone Marrow or Malignant Blood
Collection Info:
Prefer a minimum of 3.0 mL of bone marrow or 5.0 mL of malignant blood. Draw into green-top (sodium heparin) tube(s), invert several times to mix (clotted specimens may not work and can compromise results).  Label vial with the patient's name and a unique identifying number (UPHSM encounter # or MR #). Maximum time from collection should be 24 hours.
SPECIMENS CANNOT BE FROZEN

Methods

Interphase set-up and analysis of 200 cells for 11q-, +12, 13q- and 17p-; 500 cells for t(11;14).

Clinical Utilities

Detection of abnormalities involving 11q, CEN 12, 13q, and 17p most commonly associated with chronic lymphocytic leukemia (CLL). The t(11;14) probe is included to differentiate mantle cell lymphoma from CLL.

CPT Codes

88271 x 9 DNA probe, each
88275 x 5 Interphase in situ Hybridization

As needed CPT codes (additional charge):
88237 - Cell Culture-BM/Malignant Blood

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

An interpretive report will be provided.