FISH ANALYSIS MALT LYMPHOMA
General Information
HLAB/HOL Code: FISH
UPHSM LIS Test #: 1424
Schedule: Monday - Friday
Testing Time: 2 - 5 days
Testing Lab: UP Health System-Marquette
UPHSM LIS Test #: 1424
Schedule: Monday - Friday
Testing Time: 2 - 5 days
Testing Lab: UP Health System-Marquette
Specimen Info
Only 1 specimen type required, unless otherwise specified
Volume: 3.0 mL Bone Marrow or 5.0 ml Blood
Temperature: Ambient
Tube Type: Sodium heparin (green top)
Collection Info:
Bone Marrow is the tissue of choice for initial diagnosis of most neoplastic specimens. Malignant blood can be used in certain cases to monitor minimal residual disease. Prefer a minimum of 3.0 mL of bone marrow or 5.0 mL of malignant blood. Draw into green-top (sodium heparin) tube(s), invert several times to mix (clotted specimens may not work and can compromise results). Label vial with the patient's name and a unique identifying number (UPHSM encounter # or MR #). Maximum time from collection should not exceed 24 hours.
SPECIMENS CANNOT BE FROZEN.
Temperature: Ambient
Tube Type: Sodium heparin (green top)
Collection Info:
Bone Marrow is the tissue of choice for initial diagnosis of most neoplastic specimens. Malignant blood can be used in certain cases to monitor minimal residual disease. Prefer a minimum of 3.0 mL of bone marrow or 5.0 mL of malignant blood. Draw into green-top (sodium heparin) tube(s), invert several times to mix (clotted specimens may not work and can compromise results). Label vial with the patient's name and a unique identifying number (UPHSM encounter # or MR #). Maximum time from collection should not exceed 24 hours.
SPECIMENS CANNOT BE FROZEN.
Methods
Interphase analysis of cells for 7q deletion and MALT1 gene rearrangement utilizing breakapart DNA probe strategy. Detection of MALT1 gene rearrangement will be reflexed to correlating dual fusion probe strategy, t(11;18).
Clinical Utilities
Diagnosis of 7q deletion and/or BIRC3-MALT1 gene fusion characteristic of t(11;18)(q21;q21) associated with marginal zone B-cell lymphoma of Mucosa-Associated Lymphoid Tissue (MALT).
CPT Codes
88271 x4 DNA probe, each
88275 x3 Interphase in situ hybridization
As needed CPT codes (additional charge):
88237 Cell Culture-BM/Malignant
88239 Tissue culture for neoplastic disorders; solid tumor
88275 x3 Interphase in situ hybridization
As needed CPT codes (additional charge):
88237 Cell Culture-BM/Malignant
88239 Tissue culture for neoplastic disorders; solid tumor
* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
Reference Range
An interpretive report will be provided.
