IMIPRAMINE AND DESIPRAMINE SERUM

General Information

HLAB/HOL Code: IMIP
UPHSM LIS Test #: 026537
Schedule:
Testing Time: 3-5 Days
Testing Lab: Mayo

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 1.0 mL
Temperature: Refrigerate
Tube Type: Serum
Collection Info:
Collection Container/Tube: Red top (Serum gel/SST are NOT acceptable)
Collection Instructions:
1. Collect specimen immediately before next scheduled dose (minimum 12 hours after last dose).
2. Centrifuge and aliquot serum into plastic vial. Serum must be separated from cells within 2 hours of collection.

Specimen Acceptability

REJECT DUE TO:
Gross hemolysis: Reject
Gross lipemia: Reject
Gross icterus: Reject

Methods

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Clinical Utilities

Monitoring imipramine and desipramine concentrations during therapy
Evaluating potential imipramine and desipramine toxicity
The test may also be useful to evaluate patient compliance

CPT Codes

80335
G0480 (if appropriate)

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

IMIPRAMINE and DESIPRAMINE
Total therapeutic concentration: 175-300 ng/mL
Total toxic concentration: > or = 300 ng/mL
DESIPRAMINE ONLY
Total therapeutic concentration: 100-300 ng/mL
Total toxic concentration: >= 300 ng/mL