General Information

UPHSM LIS Test #: 027935
Testing Time: 2-5 Days
Testing Lab: Labcorp

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 3.0 mL Serum
Temperature: Ambient
Tube Type: Gel-Barrier Tube
Collection Info:
Container:  Gel-barrier tube, no thrombin additive.  Avoid hemolysis. Centrifuge to separate serum. SEND COMPLETE SAMPLE IN ORIGINAL TUBE, DO NOT ALIQUOT,
Stability:   Specimen is stable for 14 days at room temperature.

Patient Preparation:  Open spina bifida screening is offered for gestational ages 15 to 23 weeks. The optimal gestational age for open spina bifida screening is 16 to 18 weeks.

Special Instructions:  This test screens for open spina bifida. This test does not screen for Down syndrome or trisomy 18. The following information must be provided: gestational age, date on which the patient was the stated gestation age, how gestational age was determined (LMP, EDD, US), patient's weight, patient's date of birth, patient's race (white, black, other), and insulin-dependent diabetic status. Also indicate relevant patient history, such as prior neural tube defects, ultrasound anomalies, or previous maternal serum screening during this pregnancy. Complete information is necessary to interpret the test. Patient information may be provided to the laboratory using the Maternal Prenatal Screening request form (0900). Specimens must be collected before amniocentesis.


Chemiluminescent immunoassay

Clinical Utilities

Screening test for open neural tube defects. Detects 80% of open spina bifida and 90% of anencephaly. Please note that this test does not provide screening for Down syndrome or trisomy 18.

MS-AFP is a screening test. This test does not screen for Down syndrome or trisomy 18. A positive result means that more diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect is present.

CPT Codes


* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

See Report