NMO AQP4-IGG CBA CSF

General Information

HLAB/HOL Code: NMOCC
UPHSM LIS Test #: 026345
Schedule:
Testing Time:
Testing Lab: Mayo Labs

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 1.0(0.5) mL CSF
Temperature: Refrigerated (prefered) or Frozen
Tube Type: Sterile Vial
Collection Info:
Additional Information: Include relevant clinical information, name, phone number, mailing address, and e-mail address (if applicable) of ordering physician.

Methods

Patient's spinal fluid is applied to a composite slide containing HEK293 cells: 1) transfected with AQP4 (M1 isoform), 2) nontransfected. After incubation and washing, fluorescein-conjugated goat IgG reactive with human IgG is applied to detect bound patient IgG.(Lennon VA, Kryzer TJ, Pittock SJ, et al: IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 2005;202[4]:473-477)

Clinical Utilities

Diagnosis of a neuromyelitis optica spectrum disorder (NMOSD)



Distinguishing NMOSD from multiple sclerosis early in the course of disease

CPT Codes

86255

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

Negative