CERULOPLASMIN
General Information
HLAB/HOL Code: CRPM
UPHSM LIS Test #: 026410
Schedule:
Testing Time:
Testing Lab: Labcorp
UPHSM LIS Test #: 026410
Schedule:
Testing Time:
Testing Lab: Labcorp
Specimen Info
Only 1 specimen type required, unless otherwise specified
Volume: 1.0 mL
Temperature: Refrigerate
Tube Type: Serum (preferred) or plasma
Collection Info:
Container: Red-top tube, gel-barrier tube, or green-top (heparin) tube
Collection: Draw blood in gel-barrier tube (preferred). Separate serum or plasma from cells within 45 minutes of collection. Transfer separated serum or plasma to a plastic transport tube.
Minimum Volume: 0.2 mL (Note: This volume does not allow for repeat testing.)
Temperature: Refrigerate
Tube Type: Serum (preferred) or plasma
Collection Info:
Container: Red-top tube, gel-barrier tube, or green-top (heparin) tube
Collection: Draw blood in gel-barrier tube (preferred). Separate serum or plasma from cells within 45 minutes of collection. Transfer separated serum or plasma to a plastic transport tube.
Minimum Volume: 0.2 mL (Note: This volume does not allow for repeat testing.)
Specimen Acceptability
Cause for Rejection:
Hemolyzed specimen, specimen with improper identification
Hemolyzed specimen, specimen with improper identification
Methods
Immunologic
Clinical Utilities
Use: Decreased in most instances of Wilson's disease (hepatolenticular degeneration); hence, ceruloplasmin is used in evaluation of chronic active hepatitis, cirrhosis, and other liver disease. In Wilson's disease, there is decreased ability to incorporate copper into apoceruloplasmin. As a result, free copper levels in plasma and in tissue, especially liver and brain, are greatly increased.
Should be considered in cases of central nervous system disease of obscure etiology. Neurological symptoms include problems of coordination.
Ceruloplasmin is low in Menkes kinky hair syndrome (In Menkes syndrome the defect is secondary to poor absorption and utilization of dietary copper.) and with protein loss such as the nephrotic syndromes, malabsorption, and with some cases of advanced liver disease in which decreases of serum proteins have occurred.
Ceruloplasmin is high in a variety of neoplastic and inflammatory states, since it behaves as an acute phase reactant, although levels rise more slowly than “acute phase reactants.” Increases are described with carcinomas, leukemias, Hodgkin's disease, primary biliary cirrhosis, and with SLE and rheumatoid arthritis. High levels occur in pregnancy, with estrogens, and with oral contraceptive use when the agent contains estrogen as well as progesterone. Increased with copper intoxication.
Should be considered in cases of central nervous system disease of obscure etiology. Neurological symptoms include problems of coordination.
Ceruloplasmin is low in Menkes kinky hair syndrome (In Menkes syndrome the defect is secondary to poor absorption and utilization of dietary copper.) and with protein loss such as the nephrotic syndromes, malabsorption, and with some cases of advanced liver disease in which decreases of serum proteins have occurred.
Ceruloplasmin is high in a variety of neoplastic and inflammatory states, since it behaves as an acute phase reactant, although levels rise more slowly than “acute phase reactants.” Increases are described with carcinomas, leukemias, Hodgkin's disease, primary biliary cirrhosis, and with SLE and rheumatoid arthritis. High levels occur in pregnancy, with estrogens, and with oral contraceptive use when the agent contains estrogen as well as progesterone. Increased with copper intoxication.
CPT Codes
82390
* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
