General Information

UPHSM LIS Test #: 4684
Testing Time:
Testing Lab: Labcorp

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 25 mL aliquot (2.5 mL min)
Temperature: Ambient
Tube Type: Urine - 24 hr collection
Collection Info:
Container:  Plastic urine container with no preservative or 6N HCl
Special Instructions:  Record total 24-hour urine volume on the request form.
Collection:  Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Screw the lid on securely. Label container with patient's name, date and time collection started, and date and time collection finished. Measure and record total 24-hour volume. Mix well; send aliquot. (HCl is an acceptable preservative if required for a concurrently collected assay. PeopleSoft item number for this container is N° 21584.)

Patient Preparation:  No caffeine before or during collection. Monamine oxidase inhibitors should be discontinued at least one week prior to beginning collection.


Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Clinical Utilities

Use:  Evaluate the presence of abnormal catecholamine production, may be elevated when VMA and catecholamines are within normal limits; diagnose pheochromocytoma, neuroblastoma, and ganglioneuroblastoma

Limitations:  False-negative results occur (eg, interference by methylglucamine in x-ray contrast medium).3 False-positives can be caused by stress and drugs.

CPT Codes


* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

Pediatric and adults:

Normetanephrine (normotensive):
• 0-2 years: not established
• 3-8 years: 13-252 μg/24 hours
• 9-12 years: 32-346 μg/24 hours
• 13-17 years: 63-402 μg/24 hours
• >17 years: 82-500 μg/24 hours

Normetanephrine (hypertensive):
2 >17 years: 110-1050 μg/24 hours

Metanephrine (normotensive):
• 0-2 years: not established
• 3-8 years: 5-113 μg/24 hours
• 9-12 years: 21-154 μg/24 hours
• 13-17 years: 32-167 μg/24 hours
• >17 years: 45-290 μg/24 hours

Metanephrine (hypertensive):
2 >17 years: 35-460 μg/24 hours