ALPHA-1-ANTITRYPSIN

General Information

HLAB/HOL Code: ALAT
UPHSM LIS Test #: 7400
Schedule:
Testing Time:
Testing Lab: Labcorp

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 1.0 (0.5) mL serum or plasma
Temperature: Ambient
Tube Type: SST, red-top, EDTA, or Heparin
Collection Info:
Container:  Red-top tube, gel-barrier tube, lavender-top (EDTA) tube, or green-top (heparin) tube
Collection:  Separate serum or plasma from cells.
Patient Preparation:  Overnight fasting is preferred.
Causes for Rejection:  Chylous serum

Methods

Immunologic

Clinical Utilities

Detection of hereditary decreases in the production of α1-antitrypsin (α1AT). Decreased or nearly absent levels of α1AT can be a factor in chronic obstructive lung disease and liver disease. An increased prevalence of non-MM phenotypes is found with cryptogenic cirrhosis and with CAH. Cirrhosis in a child should raise consideration of α1AT deficiency or Wilson's disease. Diagnosis of inflammatory states, if elevated (eg, rheumatoid arthritis, bacterial infection, vasculitis, neoplasia).

Limitations:  α1AT may be elevated into normal range in heterozygous deficient patients during concurrent infection, pregnancy, estrogen therapy, steroid therapy, cancer, and during postoperative periods. Homozygous deficient patients will not show such elevation. Normal α1AT levels may occur in patients with liver disease who are heterozygotes. In normals, pregnancy and contraceptive medication may elevate levels. Levels are normally low at birth but rise soon thereafter.

CPT Codes

82103

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

90-200 mg/dL