General Information

UPHSM LIS Test #: 027190
Testing Time: 2-3 Days
Testing Lab: Labcorp

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 0.5 (0.2 min) mL
Temperature: Refrigerated
Tube Type: serum or plasma
Collection Info:
Red-top tube or gel-barrier tube for serum; or plasma may be used from blue-top (sodium citrate) tube, gray-top (sodium fluoride) tube, lavender-top (EDTA) tube, or green-top (heparin) tube

Collection:  Separate serum or plasma immediately after coagulation (30 minutes). Not removing refrigerated specimens from the clot results in aldolase levels 12% to 46% higher.

Specimen Acceptability

Rejection criteria: Hemolysis


Kinetic − 340 nm at 37°C

Clinical Utilities

Use:  Evaluate muscle wasting process. High levels are found in progressive Duchenne muscular dystrophy (MD). Elevations occur in carriers of MD, in limb-girdle dystrophy and other dystrophies, in dermatomyositis, polymyositis, and trichinosis, but not in neurogenic atrophies (eg, multiple sclerosis or in myasthenia gravis).

Limitations:  As muscle mass diminishes, aldolase decreases. Serum aldolase elevation is not specific for muscle disease since it is present in many tissues (see Additional Information).

CPT Codes


* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

0 - 30 days: Not Established
31 days - 1 year: 5.0 - 11.7 units/L
> 1 year: 3.3 - 10.3 units/L