CHROMOSOME ANALYSIS HEMATOLOGIC BONE MARROW

General Information

HLAB/HOL Code: CYG
UPHSM LIS Test #:
Schedule: Monday-Friday
Testing Time: 2 - 5 days
Testing Lab: UP Health System-Marquette

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 3.0 mL of Bone Marrow
Temperature: Ambient
Tube Type: 1 Green Top (Sodium Heparin)
Collection Info:
Note: Bone Marrow is the tissue  of choice for initial diagnosis of most neoplastic specimens. For malignant whole blood testing information please see " Chromosome Analysis, Hematologic, Blood" in the test directory. Studies on malignant blood can be informative in advanced stages of disease where abnormal cells have infiltrated to peripheral blood.  Generally, chromosome analysis will be successful if greater than 10 % blasts are present.  Procure a minimum of 3.0 mL of Bone Marrow in a green-top (sodium heparin) tube(s), invert several times to mix.  Clotted specimens may not work and can compromise results. Other anticoagulants may be harmful to the viability of the cells. Label vial with patient's name and a unique identifying number (MGHS encounter #, or MR#). Maximum time from collection should be 24 hours.
SPECIMENS CANNOT BE FROZEN.

Methods

Includes GTG banding, analysis of 20 or more metaphases, and karyograms for each cell line. Further studies, including FISH techniques, may be necessary.

Clinical Utilities

Chromosome analysis is useful for the diagnosis and classification of certain malignant hematological disorders, evaluating the prognosis in patients with certain malignant hematological disorders, monitoring the effects of treatment, and monitoring patients in remission.

CPT Codes

88237(tissue culture), 88264(chromosome analysis, 20-25 cells),
88291(Report and Interpretation). The following CPT codes may be added at additional charge if needed: 88280 (additional karyotypes), 88285 (additional cells).

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

46,XX or 46,XY. No apparent abnormality.