LACTATE DEHYDROGENASE (LDH) ISOENZYMES SERUM

General Information

HLAB/HOL Code: LDISO
UPHSM LIS Test #: 8024
Schedule: Monday, Wednesday, Friday
Testing Time: 3 - 5 Days
Testing Lab: Warde Medical Laboratories

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 2 mL (1.0 mL Min)
Temperature: Ambient
Tube Type: 1 SST Tube
Collection Info:
Do not refrigerate or freeze. Centrifuge and separate serum.
Store at ambient temperature for up to 7 days.

Specimen Acceptability

Avoid Hemolysis. Icteric and lipemic samples are not acceptable.

Methods

Agarose Electrophoresis

Clinical Utilities

The LD isoenzyme pattern is useful to evaluate the source of elevated LD activity. LD isoenzyme elevation associations: LD1: germ cell tumors; LD1>LD2: renal or myocardial infarction, megaloblastic anemia, hemolysis; LD3: platelet destruction, reactive, lymphadenopathy, lymphoma, lymphocytosis, pulmonary infarction, pneumonia, advanced cancer, acute pancreatitis; LD4, LD5: various solid tumors; LD5: primary liver disease, liver anoxia, muscle injury or dystrophy; All forms: renal disease, carcinomatosis, collagen vascular vascular disease, overwhelming sepsis, DIC.

Component Info

Name: LDH TOTAL (%LD1)
Method: KS
CPT Code: 83615
Ref Range: 2 yrs-18 yrs: 60-143 U/L, >18 yrs: 80-170 U/L
Comp Units: U/L

Name: LD ISOENZYME 1 (%LD1)
Method: AE
CPT Code: 83625
Ref Range: 16-32
Comp Units: % of Total

Name: LD ISOENZYME 2 (%LD2)
Method: AE
CPT Code: 83625
Ref Range: 29-42
Comp Units: % of Total

Name: LD ISOENZYME 3 (%LD3)
Method: AE
CPT Code: 83625
Ref Range: 17-27
Comp Units: % of Total

Name: LD ISOENZYME 4 (%LD4)
Method: AE
CPT Code: 83625
Ref Range: 6-13
Comp Units: % of Total

Name: LD ISOENZYME 5 (%LD5)
Method: AE
CPT Code: 83265
Ref Range: 3-17
Comp Units: % of Total