FISH ANALYSIS FIP1L1-PDGFRA CHIC2

General Information

HLAB/HOL Code: FISH
UPHSM LIS Test #: 2514
Schedule: Monday-Friday
Testing Time: 1-3 Days
Testing Lab: UP Health System-Marquette

Specimen Info
Only 1 specimen type required, unless otherwise specified

Volume: 3.0 mL Bone Marrow or 5.0 mL Blood
Temperature: Ambient
Tube Type: Bone Marrow or Malignant Blood
Collection Info:
Bone Marrow is the tissue of choice for initial diagnosis of most neoplastic specimens. Malignant blood can be used in certain cases to monitor minimal residual disease.  Prefer a minimum of 3.0 mL of bone marrow or 5.0 mL of malignant blood. Draw into  green-top (sodium heparin) tube(s), invert several times to mix (clotted specimens may not work and can compromise results).  Label vial with the patient's name and a unique identifying number (MGHS encounter # or MR #). Maximum time from collection should be 24 hours.
SPECIMENS CANNOT BE FROZEN

Methods

Interphase set-up and analysis. A minimum of 200 interphase nuclei will be analyzed.

Clinical Utilities

Detection of the FIP1-like 1 (FIP1L1) and platelet derived growth factor receptor alpha gene product associated with chronic hypereosinophilia with systemic mast cell disease. The FIP1L1 and PDGFR alpha fusion is a known target for imatinib mesylate therapy.

CPT Codes

88271x3, 88275x1, 88291,
88237 (as needed, at additional charge)

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding
is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Reference Range

An interpretive report will be provided.